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Description
Anti-Human VEGFR-2 Monoclonal Antibody (Ramucirumab)Product Specification Host Human Synonyms Vascular endothelial growth factor receptor 2; VEGFR 2; Fetal liver kinase 1 (FLK 1); Kinase insert domain receptor (KDR); Protein tyrosine kinase receptor flk 1; CD309; FLK1; VEGFR2; KDR Accession P35968 Clone Number Ramucirumab Antibody Type Recombinant mAb Isotype IgG1 Reactivity Human Purification Protein A Concentration 5 mg ml Endotoxin <1EU mg Conjugation Unconjugated Physical Appearance Liquid Storage
Product Specification
| Host | Human |
| Synonyms | Vascular endothelial growth factor receptor 2; VEGFR-2; Fetal liver kinase 1 (FLK-1); Kinase insert domain receptor (KDR); Protein-tyrosine kinase receptor flk-1; CD309; FLK1; VEGFR2; KDR |
| Accession | P35968 |
| Clone Number | Ramucirumab |
| Antibody Type | Recombinant mAb |
| Isotype | IgG1 |
| Reactivity | Human |
| Purification | Protein A |
| Concentration | 5 mg/ml |
| Endotoxin | <1EU/mg |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, containing no preservative |
| Stability & Storage | 2 to 8 °C for 2 weeks under sterile conditions; |
Dilution
| application | dilution | species |
| WB | Hu |
Background
VEGF Receptor 2 (VEGFR-2), also known as KDR in humans and Flk-1 in mice, is a crucial receptor tyrosine kinase that plays a central role in angiogenesis, the formation of new blood vessels. This receptor has high affinity for VEGF-A and mediates most of the endothelial growth, migration, and survival signals induced by VEGF-A. Structurally, VEGFR-2 is a glycosylated transmembrane protein with a molecular weight of about 230 kDa, consisting of an extracellular domain (ECD) for ligand binding, a transmembrane domain (TMD), a juxtamembrane domain (JMD), a tyrosine kinase domain (TKD), and a C-terminal domain (CTD) for signaling. Upon binding to VEGF-A, VEGFR-2 undergoes dimerization and autophosphorylation, activating downstream signaling pathways such as the PLCγ-PKC-MAPK pathway, which promotes endothelial cell proliferation, migration, and vascular permeability. VEGFR-2 is widely expressed in vascular endothelial cells and is also found in some tumor cells, making it a key target for both pro-angiogenic therapies in conditions like ischemic diseases and anti-angiogenic therapies in cancer.
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Exchange/Return Notes
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